Therapeutic RNA-silencing oligonucleotides in metabolic diseases
Nature Reviews Drug Discovery, Published online: 24 February 2022; doi:10.1038/s41573-022-00407-5
Advances in oligonucleotide design and delivery platforms have enabled the recent approval of several oligonucleotide-based therapies. Here, Goga and Stoffel discuss applications of RNA-silencing oligonucleotide therapeutics in metabolic diseases, recent developments in the field, ongoing challenges and possible future directions.Publisher URL: https://www.nature.com/articles/s41573-022-00407-5
DOI: 10.1038/s41573-022-00407-5
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