Nature Biotechnology
Nature Biotechnology
a year ago

Compressed Perturb-seq enables highly efficient genetic screens

Compressed Perturb-seq enables highly efficient genetic screens
Using an experimental and computational framework inspired by compressed sensing, we greatly reduced the number of measurements needed to run Perturb-seq. Our compressed Perturb-seq strategy relies on collecting measurements comprising random linear combinations of genetic perturbations, followed by deconvolving the perturbation effects on the transcriptome using sparsity-exploiting algorithms.

Publisher URL: https://www.nature.com/articles/s41587-023-02003-3

DOI: 10.1038/s41587-023-02003-3

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