Nature Reviews Immunology
Nature Reviews Immunology
9 months ago

Integrated organ immunity: a path to a universal vaccine

Integrated organ immunity: a path to a universal vaccine
Bali Pulendran
Here, I introduce the concept of 'integrated organ immunity' to explain how the innate and adaptive immune systems and non-haematopoietic cells can interact in tissues to generate enduring protective immunity against diverse pathogens in an antigen-agnostic manner. Considering immune responses through this framework could enable the design of a new class of vaccines termed 'universal vaccines' that are not pathogen specific. Considering immune responses through the framework of 'integrated organ immunity' could enable the design of a new class of universal vaccines.

Publisher URL: https://www.nature.com/articles/s41577-024-00990-1

DOI: 10.1038/s41577-024-00990-1

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