Heterocyclic azo dyes derived from 2-(6-chloro-1,3-benzothiazol-2-yl)-5-methyl-2,4-dihydro-3H-pyrazol-3-one having benzothiazole skeleton: Synthesis, structural, computational and biological studies
A series of novel benzothiazole based azo dyes were synthesized by diazotization of various substituted anilines coupling with 2-(6-chloro-1,3-benzothiazol-2-yl)-5-methyl-2,4-dihydro-3H-pyrazol-3-one by the diazo-coupling reaction at 0-5 °C. The structural confirmation of the synthesized molecules was carried out by spectroscopic techniques such as UV-visible, FT-IR and 1H NMR, respectively and by theoretical methods. Further, the computational studies were employed to interpret the structural properties of the azo molecules by using B3LYP program at 6-31G (d, p) basis set. Furthermore, the synthesized compounds were screened against cell lines to reveal their cytotoxic property, results revealed moderate to good cytotoxic potential of few compounds.
Publisher URL: https://www.sciencedirect.com/science/article/pii/S0022286021014502
DOI: 10.1016/j.molstruc.2021.131321
Keeping up-to-date with research can feel impossible, with papers being published faster than you'll ever be able to read them. That's where Researcher comes in: we're simplifying discovery and making important discussions happen. With over 19,000 sources, including peer-reviewed journals, preprints, blogs, universities, podcasts and Live events across 10 research areas, you'll never miss what's important to you. It's like social media, but better. Oh, and we should mention - it's free.
Researcher displays publicly available abstracts and doesn’t host any full article content. If the content is open access, we will direct clicks from the abstracts to the publisher website and display the PDF copy on our platform. Clicks to view the full text will be directed to the publisher website, where only users with subscriptions or access through their institution are able to view the full article.